A multi-region recurrent neural network model showing how Hebbian synaptic plasticity and transient intrinsic plasticity can support stable cortical memory representations despite ongoing hippocampal representational drift.
A computational framework for epigenetic plasticity in memory
Geoffroy Delamare, Surbhit Wagle, Johannes Gräff, and 1 more author
This work introduces epigenetic plasticity into a recurrent neural network model and explores how epigenetic priming can support memory allocation and maintenance despite synaptic turnover, noise, and loss.
2025
SpyDen: simplifying molecular and structural analysis across spines and dendrites
Maximilian F. Eggl, Surbhit Wagle, Jean P. Filling, and 3 more authors
SpyDen is an open-source platform for efficient and reproducible molecular and structural analysis of multi-channel, time-series images of neuronal spines and dendrites.
An integrative model of AMPA receptor trafficking reveals the central contribution of local translation in subtype-specific kinetics
Surbhit Wagle, Maximilian K. Kracht, Anne Bührke, and 5 more authors
This study combines computational modelling and experiments to show how local synthesis of the auxiliary subunit CNIH-2 helps explain the distinct trafficking kinetics of major AMPA-receptor subtypes after plasticity induction.
2023
Computational insights into mRNA and protein dynamics underlying synaptic plasticity rules
Surbhit Wagle, Nataliya Kraynyukova, Anne-Sophie Hafner, and 1 more author
This review brings together experimental findings and computational models of mRNA and protein dynamics to explain how molecular transport, turnover, and local translation shape synaptic plasticity.
An unguided, computerized cognitive behavioral therapy intervention (TreadWill) in a lower middle-income country: pragmatic randomized controlled trial
Arka Ghosh, Rithwik J. Cherian, Surbhit Wagle, and 4 more authors
This pragmatic randomised controlled trial evaluates TreadWill, an unguided, internet-based cognitive behavioural therapy programme for depression in India.
2021
Development and testing of a game-based digital intervention for working memory training in autism spectrum disorder
Surbhit Wagle, Arka Ghosh, P. Karthic, and 5 more authors
This study presents five smartphone games designed through iterative user testing to train working memory in autistic children and reports a pilot evaluation of their feasibility and initial efficacy.