Surbhit Wagle

Research Scientist · Computational Neuroscience · Neuro-AI

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Imperial College London

London, UK

I am a computational neuroscientist and research scientist with a PhD in Neuroscience, working at the intersection of recurrent and oscillatory neural dynamics, synaptic and intrinsic plasticity, memory, and machine learning. I develop mathematically grounded models of neural and molecular dynamics and translate them into scalable Python and PyTorch simulations.

I am currently a Postdoctoral Research Associate in Prof. Claudia Clopath’s group at Imperial College London. My research includes multi-region recurrent neural networks, Hebbian learning, activity-dependent intrinsic plasticity, representational drift, memory consolidation, and neural population dynamics. I also work on learning-evoked oscillatory dynamics and offline memory reactivation.

My doctoral research, supervised by Prof. Tatjana Tchumatchenko, combined computational models of molecular transport and receptor trafficking with experimental measurements to study mechanisms of synaptic plasticity. I also co-developed SpyDen, an open-source platform for reproducible molecular and structural analysis of neuronal images.

My broader experience spans numerical simulation, statistical modelling, computer vision, high-performance computing, and reproducible research software. Before my PhD, I developed distributed optimisation pipelines and scientific web applications at the National Centre for Biological Sciences and the Institute for Stem Cell Science and Regenerative Medicine in India.

selected publications

  1. Transient excitability and synaptic consolidation support stable memory despite neural drift
    Surbhit Wagle and Claudia Clopath
    2026
    Manuscript submitted
  2. A computational framework for epigenetic plasticity in memory
    Geoffroy Delamare, Surbhit Wagle, Johannes Gräff, and 1 more author
    Brain, Mar 2026
  3. SpyDen: simplifying molecular and structural analysis across spines and dendrites
    Maximilian F. Eggl, Surbhit Wagle, Jean P. Filling, and 3 more authors
    Bioinformatics, Jun 2025
  4. An integrative model of AMPA receptor trafficking reveals the central contribution of local translation in subtype-specific kinetics
    Surbhit Wagle, Maximilian K. Kracht, Anne Bührke, and 5 more authors
    bioRxiv, 2025
    Preprint; under review