Surbhit Wagle

Surbhit Wagle

Computational neuroscientist working on models of synaptic plasticity and protein trafficking

Publications

You can also find my articles on my Google Scholar profile.

Journal Articles

An integrative model of AMPA receptor trafficking reveals the central contribution of local translation in subtype-specific kinetics Permalink

Published in bioRxiv, 2025

This study proposes a model for AMPA receptor trafficking, showing how local translation governs kinetic properties across receptor subtypes.

Recommended citation: Wagle, S., Kracht, M. K., Bührke, A., Acker-Palmer, A., Kraynyukova, N., Hafner, A.-S., Schuman, E. M., & Tchumatchenko, T. (2025). An integrative model of AMPA receptor trafficking reveals the central contribution of local translation in subtype-specific kinetics. *bioRxiv*. https://doi.org/10.1101/2025.02.08.637220

SpyDen: Automating molecular and structural analysis across spines and dendrites Permalink

Published in Biofinrmatics (Oxford Press), 2024

SpyDen introduces an automated platform to analyze spine and dendrite structures, streamlining molecular neuroanatomical analysis.

Recommended citation: Eggl, M. F., Wagle, S., Filling, J. P., Chater, T. E., Goda, Y., & Tchumatchenko, T. (2024). SpyDen: Automating molecular and structural analysis across spines and dendrites. https://doi.org/10.1093/bioinformatics/btaf339

An Unguided, Computerized Cognitive Behavioral Therapy Intervention (TreadWill) in a Lower Middle-Income Country: Pragmatic Randomized Controlled Trial Permalink

Published in Journal of Medical Internet Research, 2023

This RCT evaluates TreadWill, an unguided computerized CBT program, finding it effective in reducing depression in a lower middle-income country.

Recommended citation: Ghosh, A., Cherian, R. J., Wagle, S., Sharma, P., Kannan, K. R., Bajpai, A., & Gupta, N. (2023). An Unguided, Computerized Cognitive Behavioral Therapy Intervention (TreadWill) in a Lower Middle-Income Country: Pragmatic Randomized Controlled Trial. *Journal of Medical Internet Research, 25*, e41005. https://doi.org/10.2196/41005

Computational insights into mRNA and protein dynamics underlying synaptic plasticity rules Permalink

Published in Molecular and Cellular Neuroscience, 2023

The paper presents computational models to understand the roles of mRNA and protein dynamics in synaptic plasticity, highlighting the importance of local translation.

Recommended citation: Wagle, S., Kraynyukova, N., Hafner, A. S., & Tchumatchenko, T. (2023). Computational insights into mRNA and protein dynamics underlying synaptic plasticity rules. *Molecular and Cellular Neuroscience, 125*, 103846. https://doi.org/10.1016/j.mcn.2023.103846

Development and testing of a game-based digital intervention for working memory training in autism spectrum disorder Permalink

Published in Scientific Reports, 2021

This study introduces and evaluates a game-based digital intervention aimed at improving working memory in individuals with autism spectrum disorder.

Recommended citation: Wagle, S., Ghosh, A., Karthic, P., Ghosh, A., Pervaiz, T., Kapoor, R., Patil, K., & Gupta, N. (2021). Development and testing of a game-based digital intervention for working memory training in autism spectrum disorder. *Scientific Reports, 11*(1), 13800. https://doi.org/10.1038/s41598-021-93258-w